CuspAI has secured $450 million in a Series B funding round, drawing support from Jeff Bezos and a UK government-backed venture fund focused on homegrown artificial intelligence companies. The investment marks a major vote of confidence in a British startup working at the intersection of AI, materials science and industrial innovation.

The company is developing AI systems aimed at discovering and designing new materials. Its work is positioned around two strategically important areas: clean energy and chipmaking, both of which depend on advances in materials to improve performance, efficiency and manufacturing.

The backing highlights growing investor interest in AI businesses that go beyond chatbots and software tools to tackle harder scientific and engineering problems. Materials discovery has become a key area for AI because faster design cycles could help shorten the path from research to real-world applications.

The deal also underscores the UK’s push to support domestic AI champions through public-backed investment vehicles. With fresh capital from this large Series B round, CuspAI is set to expand its efforts in using AI to accelerate breakthroughs in sectors seen as critical to future economic and technological competitiveness.