A Nature feature examines how foresight can strengthen research planning from the very beginning. The central idea is that every research programme depends on assumptions about the future, yet those assumptions are often left untested as projects move ahead.

The article argues that researchers can reduce later problems by thinking early about the different ways a programme might unfold. That includes considering not only the best-case outcome, but also delays, setbacks, changing evidence and other factors that could alter the direction of the work.

This approach matters because research choices are tied to bigger institutional decisions. Funding, infrastructure, hiring, regulation and training can all be shaped by expectations about how a field will develop, so weak assumptions at the start can create costly issues later.

Rather than trying to predict one exact future, the piece presents foresight as a practical way to build resilience into science strategy. By stress-testing plans against multiple possible outcomes, research teams may be better positioned to adapt and keep long-term programmes on track.